The Blood-Brain Barrier prevents many therapeutics accessing the brain. Even if overcome, many therapies require effective doses to be confined to specific brain targets. Existing methods for one-time direct administration of therapies to targeted areas deep within the brain are complex, requiring expensive equipment and long procedure times. Additionally, many available in-dwelling catheters for treatments requiring chronic infusions (which?) are suboptimal. The Neurochase CED medical device is designed to revolutionise how neurodegenerative diseases are treated. We aim to significantly reduce procedure times and improve the patient experience with our fast, accurate, and highly-scalable procedure for both acute and chronic infusions.* Neurochase is the leading global biotechnology company focused exclusively on innovative devices and consulting services for CNS drug delivery.
*Currently for investigational use only. Not approved for clinical use in any geography.
Animation of how a catheter is inserted into a specific target area of the brain using the Neurochase system
Effective
Our innovative micro-fluted cannula with an adjustable step-length enables distribution to be shaped to match individual treatment volumes.
Efficient
Minimises operating room time with each cannula insertion and fixation circa 10-minutes. Reduces infusion procedure time with simultaneous infusions of up to eight cannulas per patient on the ward. Bedside removal of cannulas.
Scaleable
Implantation using widely available stereotactic frames and robots. Cost-effective procedures are driven by simultaneous infusions in awake patients enabling effective use of the OR and staff.
Workflow
The Neurochase system is designed to optimize the patient, surgeon and hospital experience for drug delivery procedures by (significantly) reducing OR time, minimizing time (duration patient is) under anesthesia, and allowing for awake neurological exams during infusions.
Planning MRI Scan
The planning MRI scan is done as an outpatient.
Surgery (1 to 2 hours)
Patient brought to OR for procedure under general anesthesia. On table registration to plan using widely available stereotactic frames or robots. Cannula Implantation (10 minutes per cannula). On table confirmation of catheter placement. Patient transferred to recovery room and awakened.
(2-4 hours) Infusions
Simultaneous infusions on the ward/floor with patients free to relax, read, watch TV, etc.
Infusions monitored with MRI and neuro observations
Cannula removal
With local anesthetic
Overnight for observation
Patient Returns Home
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